Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics.

نویسندگان

  • Kaimin Cai
  • Jonathan Yen
  • Qian Yin
  • Yang Liu
  • Ziyuan Song
  • Stéphane Lezmi
  • Yanfeng Zhang
  • Xujuan Yang
  • William G Helferich
  • Jianjun Cheng
چکیده

We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

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عنوان ژورنال:
  • Biomaterials science

دوره 3 7  شماره 

صفحات  -

تاریخ انتشار 2015